Difficulties in Emotion Regulation and Psychopathic Traits in Violent Offenders

Purpose: The present study aimed to advance our understanding of the relevance of emotion dysregulation (ED) for psychopathy. Methods: Latent Profile Analysis (LPA) and Structural Equation Modeling (SEM) were employed to examine person- and variable-centered associations between ED domains and psychopathic traits in a moderately-large (N=268) sample of violent male offenders. Results: LPA results indicated a 3-class solution with offenders most accurately classified based on ED levels (low, medium, high) across domains. The three ED subgroups revealed linear positive associations with psychopathy total, affective, and lifestyle facet scores, such that elevated levels of these traits were found in subgroups with greater ED. A similar linear trend emerged for the antisocial \u2013 but not interpersonal \u2013 facet, in-line with recent studies showing positive associations between executive functioning and interpersonal features of psychopathy. In SEM analyses, a latent ED factor positively predicted a super-ordinate psychopathy factor, controlling for psychopathological distress. Conclusions: Taken together, current findings support the notion that ED involves broad difficulties across emotion regulation domains, which vary by degree rather than in kind, and that these difficulties have linear positive relations with psychopathic traits among violent offenders

Single and Multiple Clinical Syndromes in Incarcerated Offenders

The present study examined the prevalence and correlates of clinical syndromes in a large group (N = 438) of incarcerated violent offenders, looking at differences between inmates with one and those with more than one clinical syndromes. More than a half of the sample (57%) reported clinically relevant symptoms for at least one clinical syndrome (n = 252), and the majority of them (38%) reported more syndromes in comorbidity (n = 169). Increased severity of clinical conditions (none, one, more than one syndrome) corresponded with significantly greater levels of personality disorder traits, psychological symptoms, dissociation, and negative emotionality, with large effect sizes. After controlling for co-occurrence of personality disorder traits and other symptoms, the presence of more than one comorbid syndrome significantly predicted unique variance in dissociation (positively) and positive emotionality (negatively). The presence of one clinical syndrome significantly and positively predicted negative emotionality. Findings support the possibility that the complexity, and not just the presence, of psychopathology could identify different groups of inmates

Obesity hormone leptin: a new target in breast cancer?

Leptin is a multifunctional hormone produced mainly by the adipose tissue and involved in the regulation of food intake and energy balance. In addition, leptin can stimulate mitogenic and angiogenic processes in peripheral organs. Because leptin levels are elevated in obese individuals and excess body weight has been shown to increase breast cancer risk in postmenopausal women, attempts have been made to evaluate whether leptin can promote breast cancer. Data obtained in cell and animal models and analyses of human breast cancer biopsies indeed suggest such an involvement. Furthermore, a recent report clearly shows that targeting leptin signaling may reduce mammary carcinogenesis. Thus, leptin should become a new attractive target in breast cancer

Three-dimensional geometry, ore distribution and time-integrated mass transfer through the quartz-tourmaline-gold vein network of the Sigma deposit (Abitibi belt, Canada)

We present a reconstruction of the three-dimensional (3D) geometry and gold grade distribution of shear zone-hosted, Au-mineralized, quartz-tourmaline veins of the Sigma deposit (Abitibi belt). Host shears and veins form a network of anastomosing, steeply dipping structures associated with smaller subhorizontal extensional veins. Our reconstruction has been carried out using the exceptionally large geological database of the mine. From this database, we extracted the geometric position, thickness and gold grades of geometrically best-defined steep veins contained in a representative subvolume of the deposit. These data allowed the 3D representation of 53 veins, which have been constructed by fitting surfaces through the geometrical data and by contouring thickness and gold grade. The geometry of the network is mainly characterized by: (i) a few large segmented veins, with sinuous and helicoidal shape, and typical vertical dimension of >100 m; (ii) a large number of smaller vertical veins, some of which splay off the steep veins with high dip angles; (iii) subhorizontal extension veins (joints) located at, or close to, the tips of steep veins. The absolute thickness of the vertically short veins is the same as that of the large veins, suggesting that they formed simultaneously, but only a few of them interconnect to form vertically continuous bodies. Patchy, vertically elongated zones of high dilation are present in the large veins, and are poorly correlated with Au-rich zones. They presumably represent former high-permeability zones of the network. The highest gold grades occur at the interconnections between the large veins and small splays or subhorizontal joints. This indicates the important role of vein interconnection for fluid flow and gold precipitation within the network. Combining the calculation of the volume of the network with the estimation of tourmaline abundance in the veins, we calculate that 2.1 × 106 m3 of tourmaline and 3.2 × 106 m3 of quartz precipitated during Au deposition

Minimal invasive surgery for coronoid fracture: technical note

Operative treatment of coronoid fracture often requires a large dissection of soft tissue, resulting in elbow stiffness and functional limitation. The authors present a minimal invasive, safe technique, useful in the case of isolated coronoid fracture associated with elbow dislocation. This technique does not require soft tissue dissection and allows an early unlimited resumption of sports activitie

Grandiose and vulnerable narcissism, identity integration and self-control related to criminal behavior

BACKGROUND: Although systematic research on narcissism has been conducted for over 100 years, researchers have only recently started to distinguish between grandiose and vulnerable narcissism in relation to criminal behavior. In addition, there is some evidence suggesting that identity integration and self-control may underlie this association. Therefore, the present study aimed to develop a theory-driven hypothetical model that investigates the complex associations between grandiose and vulnerable narcissism, identity integration, self-control, and criminal behavior using structural equation modeling (SEM). METHODS: The total sample (N = 222) included 65 (29.3%) individuals convicted of criminal behavior and 157 (70.7%) participants from the community, with a mean age of 37.71 years (SD = 13.25). Criminal behavior was a grouping variable used as a categorical outcome, whereas self-report questionnaires were used to assess grandiose and vulnerable narcissism, self-control, and identity integration. RESULTS: The overall SEM model yielded good fit indices. Grandiose narcissism negatively predicted criminal behavior above and beyond the influence of identity integration and self-control. In contrast, vulnerable narcissism did not have a direct significant effect on criminal behavior, but it was indirectly and positively associated with criminal behavior via identity integration and self-control. Moreover, grandiose narcissism was positively, whereas vulnerable narcissism was negatively associated with identity integration. However, identity integration did not have a direct significant effect on criminal behavior, but it was indirectly and negatively associated with criminal behavior via self-control. Finally, self-control was, in turn, negatively related to criminal behavior. CONCLUSIONS: We propose that both subtypes of narcissism should be carefully considered in clinical assessment and current intervention practices. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s40359-021-00697-1

Emotional, cognitive and behavioral self-regulation in forensic psychiatric patients:Changes over time and associations with childhood trauma, identity and personality pathology

The construct of self-regulation is of particular interest to the forensic psychiatric practice due to its associations with both clinical and criminal outcomes, as well as recidivism. However, research on different components of self-regulation within forensic psychiatric practice is rare. The current study aimed to gain knowledge on the construct of self-regulation in a sample of forensic psychiatric patients (N = 94). Firstly, by investigating change of emotional, behavioral and cognitive self-regulation over the course of 12 months in state-mandated care in a treatment facility. Secondly, by looking at the associations between these three elements of self-regulation and childhood trauma, identity dysfunction and personality pathology. Repeated measures ANOVA showed little to no difference in average self-regulation over time (only for behavioral regulation), and rank-order stability was relatively high in most cases. Path analysis showed that: emotion regulation was associated with all outcomes; behavioral regulation with all except childhood trauma and detachment; and cognitive regulation only with antagonism and negative affectivity. Findings suggest short-term changes are unlikely and indicate relative importance of emotional, and to some extent behavioral regulation for clinical practice. However, due to sample size restrictions, interpretations should be made with caution

Nonlinear diffusion & thermo-electric coupling in a two-variable model of cardiac action potential

This work reports the results of the theoretical investigation of nonlinear dynamics and spiral wave breakup in a generalized two-variable model of cardiac action potential accounting for thermo-electric coupling and diffusion nonlinearities. As customary in excitable media, the common Q10 and Moore factors are used to describe thermo-electric feedback in a 10-degrees range. Motivated by the porous nature of the cardiac tissue, in this study we also propose a nonlinear Fickian flux formulated by Taylor expanding the voltage dependent diffusion coefficient up to quadratic terms. A fine tuning of the diffusive parameters is performed a priori to match the conduction velocity of the equivalent cable model. The resulting combined effects are then studied by numerically simulating different stimulation protocols on a one-dimensional cable. Model features are compared in terms of action potential morphology, restitution curves, frequency spectra and spatio-temporal phase differences. Two-dimensional long-run simulations are finally performed to characterize spiral breakup during sustained fibrillation at different thermal states. Temperature and nonlinear diffusion effects are found to impact the repolarization phase of the action potential wave with non-monotone patterns and to increase the propensity of arrhythmogenesis